Thyroglobulin (TG) is the precursor of the thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). Autoantibodies against thyroglobulin (aTG) is an in-vitro assay used to aid in the diagnosis of Hashimoto’s and Grave’s disease, both of which are autoimmune diseases affecting the thyroid gland, as well as other thyroid disorders.
Symptoms of hypothyroidism (underactive thyroid) include but are not limited to fatigue, lethargy, mental impairment, hair loss, weight gain, depression, cold intolerance, etc. Symptoms of hyperthyroidism (overactive thyroid) include but are not limited to hyperactivity, weakness, palpitations, tremors, heat intolerance, weight gain, etc.
It is noted that approximately 82-100% of patients with Hashimoto’s thyroiditis and 60-70% of patients with Graves disease are anti-thyroglobulin antibody positive. aTG can be measured using a variety of methods including indirect immunofluorescence, agar gel diffusion precipitin, agglutination, RIA, complete fixation, ELISA, or chemiluminescence.
Solaris diagnostics aTG assay is a competitive immunoassay (IM) using direct chemiluminescent technology on an IM analyzer to determine the amount of aTG in patient samples, with results typically ready in 24 hours after receipt of the sample.
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