Prostate Specific Antigen (PSA), Total

CPT: 84153

Expected Turnaround Time

24 Hours

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum

Container

SST (Serum), Red Top (Separate Serum)

Storage Instructions

Room Temp., Refrigerated (2-8 C)

Stability Requirements

Room temp. 7 days, Refrigerated 7 days

Test Details

Additional Information

The PSA Total test measures the levels of prostate-specific antigen (PSA) in the blood. PSA is a protein produced by the cells of the prostate gland. The PSA Total test is commonly used as a screening tool for prostate cancer and to monitor the progression of the disease. It provides valuable information about prostate health and helps detect potential abnormalities. 

There are two types of PSA, complex and free, and this test will measure the total sum of both. 

PSA is a protein produced predominantly by cells in the prostate, a tiny gland that surrounds the urethra in males and generates a fluid that is a component of semen. The majority of PSA produced by the prostate is discharged into this fluid, but minor amounts can also be found in the blood. This test determines how much PSA is present in the blood. 

In the blood, PSA is found in two forms: complexed and free. The total PSA test, which analyzes the sum of complexed and free PSA in the blood, is the most often used PSA test. 

When the total PSA is only slightly raised, the free PSA test is occasionally used to help assess whether a biopsy should be performed. PSA is an enzyme, and when it is released into the blood, some circulating proteins link to it and inactivate it. IAs a result, men with BPH tend to have greater levels of free PSA, while men with prostate cancer have lower levels. Even if total PSA is not dramatically raised, a relatively low amount of free PSA raises the chances of cancer. 

The total PSA test and DRE may also be ordered when a man has symptoms that could be due to prostate cancer, such as difficult, painful, and/or frequent urination, back pain, and/or pelvic pain. Since these symptoms are seen with a variety of other conditions, including infection and prostatitis, the doctor will also frequently order other tests, such as a urine culture. Some of these conditions can themselves cause temporary increases in PSA levels.   

Footnotes

  1. Centers for Disease Control and Prevention [Internet]. Atlanta: U.S. Department of Health and Human Services; Should I Get Screened for Prostate Cancer? [reviewed 2021 Aug 23; cited 2022 May 16]; [about 2 screens]. Available from: https://www.cdc.gov/cancer/prostate/basic_info/get-screened.htm 
  2. Ilic D, Djulbegovic M, Jung JH, Hwang EC, et al. Prostate cancer screening with prostate-specific antigen (PSA) test: A systematic review and meta-analysis. British Medical Journal 2018; 362:k3519. [PubMed Abstract] 
  3. Barry MJ. Clinical practice. Prostate-specific-antigen testing for early diagnosis of prostate cancer. New England Journal of Medicine 2001; 344(18):1373–1377. [PubMed Abstract] 

Statement on Medical Necessity
All ordered tests should be medically necessary for the diagnosis or detection of disease, illness, impairment, symptom, syndrome, or disorder and the results should be used in the medical management and treatment decisions for the patient. Solaris requires ICD-10 codes with each order for lab testing and both the tests ordered and the diagnosis should be documented in the provider’s medical record for the patient. The United States Department of Health and Human Services, Office of Inspector General, takes the position that a provider who orders medically unnecessary tests may be subject to civil penalties.

Panels and Profiles
Solaris offers Providers the convenience of ordering test combinations in a group at times with the flexibility to choose appropriate test(s) for individual patients. Providers should only order those tests that he or she believes are medically necessary for each patient, and a lesser inclusive profile or individual tests should be ordered if not all tests in the test combination/profile are medically necessary. All tests offered in a test combination/profile may be ordered separately as individual tests. Solaris encourages clients to contact their Solaris representative if the testing configurations shown do not meet individual needs for any reason, or if some other combination of procedures is needed.

CPT Codes
CPT Codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are the responsibility of the billing party and are listed here for informational purposes. Correct coding may vary from one carrier to another. Solaris may bill specific carriers using codes other than what is shown.

Questions?

For questions or inquiries related to testing please reach out to
customerservice@solarisdx.com or contact us by phone at (844) 550-0308.