RPR (Rapid Plasma Reagin) (Syphilis) with titer

CPT: 86592

Test Includes

RPR

Titer if positive

Expected Turnaround Time

24 Hours

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum, Plasma

Volume

5 ml

Minimum Volume

50 ul

Container

SST (Serum), Red Top (Separate Serum), Lihium Heparin (Plasma), Sodium Heparin (Plasma)

Storage Instructions

Room Temp., Refrigerated (2-8 C)

Stability Requirements

Room temp. 5 days, Refrigerated 5 days

Causes for Rejection

Mislabeled specimen, sample collected expired tubes, clotted specimen, QNS

Test Details

Use

This test is use for the qualitative and quantitative detection of reagin antibodies in serum or plasma.

Methodology

carbon flocculation

Reference Interval

Negative

Additional Information

The RPR test is a non-treponemal serologic assay used to screen for syphilis by detecting antibodies to cardiolipin-cholesterol-lecithin antigens. Quantitative RPR titers measure the amount of antibody present and are useful for assessing disease activity and monitoring response to treatment.

RPR titers typically correlate with disease stage: higher titers are seen in active infection, while declining titers indicate successful therapy. False-positive results can occur in other infections, autoimmune conditions, pregnancy, or older age, so confirmatory treponemal testing is recommended for diagnosis.

References:

  1. Larsen SA et al. Manual of Serologic Testing for Syphilis. 2001.

  2. Workowski KA, Bolan GA. Sexually transmitted infections treatment guidelines, 2015. MMWR Recomm Rep. 2015;64:1–137.

Footnotes

Statement on Medical Necessity
All ordered tests should be medically necessary for the diagnosis or detection of disease, illness, impairment, symptom, syndrome, or disorder and the results should be used in the medical management and treatment decisions for the patient. Solaris requires ICD-10 codes with each order for lab testing and both the tests ordered and the diagnosis should be documented in the provider’s medical record for the patient. The United States Department of Health and Human Services, Office of Inspector General, takes the position that a provider who orders medically unnecessary tests may be subject to civil penalties.

Panels and Profiles
Solaris offers Providers the convenience of ordering test combinations in a group at times with the flexibility to choose appropriate test(s) for individual patients. Providers should only order those tests that he or she believes are medically necessary for each patient, and a lesser inclusive profile or individual tests should be ordered if not all tests in the test combination/profile are medically necessary. All tests offered in a test combination/profile may be ordered separately as individual tests. Solaris encourages clients to contact their Solaris representative if the testing configurations shown do not meet individual needs for any reason, or if some other combination of procedures is needed.

CPT Codes
CPT Codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are the responsibility of the billing party and are listed here for informational purposes. Correct coding may vary from one carrier to another. Solaris may bill specific carriers using codes other than what is shown.

Questions?

For questions or inquiries related to testing please reach out to
customerservice@solarisdx.com or contact us by phone at (844) 550-0308.