Folate

CPT: 82746

Expected Turnaround Time

24 Hours

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum

Container

SST (Serum), Red Top (Separate Serum)

Storage Instructions

Room Temp., Refrigerated (2-8 C)

Stability Requirements

Room temp. 48hrs., Refrigerated 7 days

Test Details

Additional Information

Folate is the natural form of vitamin B9, water-soluble and naturally found in many foods. It is also added to foods and sold as a supplement in the form of folic acid; this form is actually better absorbed than that from food sources – 85% vs. 50%, respectively.

Folate helps to form DNA and RNA and is involved in protein metabolism. It plays a key role in breaking down homocysteine, an amino acid that can exert harmful effects on the body if it is present in high amounts. Folate is also needed to produce healthy red blood cells and is critical during periods of rapid growth, such as during pregnancy and fetal development. 

A folate test measures the amount of folate in the blood. Folate is one of many B vitamins. The body needs folate for normal growth and to make red blood cells (RBC), white blood cells (WBC), and platelets. Folate is also important for the normal development of a baby (fetus). 

Folate can be measured in the liquid portion of the blood (plasma). This reflects the body’s recent intake of folate and folic acid by way of diet. Folate is found in foods such as liver; citrus fruits; dark green, leafy vegetables (spinach); whole grains; and beans. Folic acid is the man-made form of folate. It’s found in vitamin pills and fortified foods, such as fortified breakfast cereals.  

Folate deficiency can result in a type of anemia called megaloblastic anemia. Mild folate deficiency often does not cause any symptoms. Severe folate deficiency may cause a sore tongue, diarrhea, weakness, forgetfulness, and fatigue. 

Footnotes

  1. Farrell CJ, Kirsch SH, Herrmann M. Red Cell or Serum Folate: What To Do in Clinical Practice? Clin Chem Lab Med. 2013;51(3):555-569. doi:10.1515/cclm-2012-0639 
  2. Harvard School of Public Health. The Nutrition Source: Vitamins. Available at: http://www.hsph.harvard.edu/nutritionsource/vitamins.html. Accessed June 14, 2011. 

Statement on Medical Necessity
All ordered tests should be medically necessary for the diagnosis or detection of disease, illness, impairment, symptom, syndrome, or disorder and the results should be used in the medical management and treatment decisions for the patient. Solaris requires ICD-10 codes with each order for lab testing and both the tests ordered and the diagnosis should be documented in the provider’s medical record for the patient. The United States Department of Health and Human Services, Office of Inspector General, takes the position that a provider who orders medically unnecessary tests may be subject to civil penalties.

Panels and Profiles
Solaris offers Providers the convenience of ordering test combinations in a group at times with the flexibility to choose appropriate test(s) for individual patients. Providers should only order those tests that he or she believes are medically necessary for each patient, and a lesser inclusive profile or individual tests should be ordered if not all tests in the test combination/profile are medically necessary. All tests offered in a test combination/profile may be ordered separately as individual tests. Solaris encourages clients to contact their Solaris representative if the testing configurations shown do not meet individual needs for any reason, or if some other combination of procedures is needed.

CPT Codes
CPT Codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are the responsibility of the billing party and are listed here for informational purposes. Correct coding may vary from one carrier to another. Solaris may bill specific carriers using codes other than what is shown.

Questions?

For questions or inquiries related to testing please reach out to
customerservice@solarisdx.com or contact us by phone at (844) 550-0308.