Herpes Simplex 1 IgG (HSV-1)

CPT: 86695

Expected Turnaround Time

24 Hours

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum, Plasma

Volume

5 ml

Minimum Volume

20 ul

Container

SST (Serum), Red Top (Separate Serum), Lithium Heparin (Plasma), EDTA (Plasma)

Storage Instructions

Room Temp., Refrigerated (2-8 C)

Stability Requirements

Room temp. 7 days, Refrigerated 7 days

Causes for Rejection

Incorrect labeling, incorrect anticoagulant, frozen gel-barrier tube, mislabeled samples

Test Details

Use

This assay is use in the qualitative determination of IgG antibodies to herpes simplex virus type 1 (HSV-1) in human serum and plasma (EDTA and lithium heparin)

Methodology

Electrochemiluminescience immunoassay

Reference Interval

Non- Reactive

Additional Information

Herpes Simplex Virus Type 1 (HSV-1) IgG antibody testing is a serological method used to detect past exposure to HSV-1. IgG antibodies typically appear within weeks after initial infection and remain detectable for life, serving as a marker of prior or latent infection. The test is commonly used in asymptomatic individuals, in prenatal screening, or to differentiate between HSV-1 and HSV-2 in patients with genital lesions. A positive HSV-1 IgG result indicates previous infection but does not distinguish between oral or genital location or confirm active disease. This test is not useful for diagnosing acute infection, where PCR or viral culture from lesion samples is preferred. Negative results suggest no prior exposure, but early testing after infection may yield false negatives due to the window period.

References

Ashley-Morrow, R., Krantz, E., & Wald, A. (2003). Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2. Sexually Transmitted Diseases, 30(4), 310–314. https://doi.org/10.1097/00007435-200304000-00011

Centers for Disease Control and Prevention (CDC). (2021). Genital herpes—CDC fact sheet. Retrieved from https://www.cdc.gov/std/herpes/stdfact-herpes.htm

Wald, A., & Corey, L. (2007). Persistence in the population: Epidemiology, transmission. In A. A. Arvin et al. (Eds.), Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press.

Footnotes

Statement on Medical Necessity
All ordered tests should be medically necessary for the diagnosis or detection of disease, illness, impairment, symptom, syndrome, or disorder and the results should be used in the medical management and treatment decisions for the patient. Solaris requires ICD-10 codes with each order for lab testing and both the tests ordered and the diagnosis should be documented in the provider’s medical record for the patient. The United States Department of Health and Human Services, Office of Inspector General, takes the position that a provider who orders medically unnecessary tests may be subject to civil penalties.

Panels and Profiles
Solaris offers Providers the convenience of ordering test combinations in a group at times with the flexibility to choose appropriate test(s) for individual patients. Providers should only order those tests that he or she believes are medically necessary for each patient, and a lesser inclusive profile or individual tests should be ordered if not all tests in the test combination/profile are medically necessary. All tests offered in a test combination/profile may be ordered separately as individual tests. Solaris encourages clients to contact their Solaris representative if the testing configurations shown do not meet individual needs for any reason, or if some other combination of procedures is needed.

CPT Codes
CPT Codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are the responsibility of the billing party and are listed here for informational purposes. Correct coding may vary from one carrier to another. Solaris may bill specific carriers using codes other than what is shown.

Questions?

For questions or inquiries related to testing please reach out to
customerservice@solarisdx.com or contact us by phone at (844) 550-0308.