Human Metapneumovirus A
Human Metapneumovirus B
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Human Metapneumovirus (hMPV) is a respiratory virus classified within the Paramyxoviridae family and is closely related to respiratory syncytial virus (RSV). It is divided into two major genetic subgroups, hMPV A and hMPV B, both of which can cause similar clinical syndromes. These subtypes are further divided into sublineages (e.g., A1, A2, B1, B2) based on variations in the fusion (F) and glycoprotein (G) genes. Infections with either type can lead to upper and lower respiratory tract illnesses, such as bronchiolitis, pneumonia, and asthma exacerbations—particularly in infants, the elderly, and immunocompromised individuals.
Diagnosis is primarily achieved using nucleic acid amplification tests (NAATs) such as real-time reverse transcription polymerase chain reaction (RT-PCR), which can differentiate between types A and B if subtype-specific assays are used. While both subgroups co-circulate seasonally, studies suggest that type A infections may be associated with more severe disease, although this is still under investigation.
References
van den Hoogen, B. G., van Doornum, G. J., Fockens, J. C., Cornelissen, J. J., Beyer, W. E., de Groot, R., … & Osterhaus, A. D. (2003). Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. The Journal of Infectious Diseases, 188(10), 1571–1577. https://doi.org/10.1086/379200
Boivin, G., De Serres, G., Côté, S., Gilca, R., Abed, Y., Rochette, L., … & Déry, P. (2003). Human metapneumovirus infections in hospitalized children. Emerging Infectious Diseases, 9(6), 634–640. https://doi.org/10.3201/eid0906.020568
Bastien, N., Ward, D., van Caeseele, P., Brandt, K., Lee, S. H., McNabb, G., … & Li, Y. (2003). Human metapneumovirus infection in the Canadian population. Journal of Clinical Microbiology, 41(10), 4642–4646. https://doi.org/10.1128/JCM.41.10.4642-4646.2003
Statement on Medical Necessity
All ordered tests should be medically necessary for the diagnosis or detection of disease, illness, impairment, symptom, syndrome, or disorder and the results should be used in the medical management and treatment decisions for the patient. Solaris requires ICD-10 codes with each order for lab testing and both the tests ordered and the diagnosis should be documented in the provider’s medical record for the patient. The United States Department of Health and Human Services, Office of Inspector General, takes the position that a provider who orders medically unnecessary tests may be subject to civil penalties.
Panels and Profiles
Solaris offers Providers the convenience of ordering test combinations in a group at times with the flexibility to choose appropriate test(s) for individual patients. Providers should only order those tests that he or she believes are medically necessary for each patient, and a lesser inclusive profile or individual tests should be ordered if not all tests in the test combination/profile are medically necessary. All tests offered in a test combination/profile may be ordered separately as individual tests. Solaris encourages clients to contact their Solaris representative if the testing configurations shown do not meet individual needs for any reason, or if some other combination of procedures is needed.
CPT Codes
CPT Codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are the responsibility of the billing party and are listed here for informational purposes. Correct coding may vary from one carrier to another. Solaris may bill specific carriers using codes other than what is shown.
For questions or inquiries related to testing please reach out to
customerservice@solarisdx.com or contact us by phone at (844) 550-0308.
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