Lipase

CPT: 83690

Expected Turnaround Time

24 Hours

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum, Plasma

Volume

5 ml

Minimum Volume

2 ul

Container

SST (Serum), Red Top (Separate Serum), Lithium Heparin (Plasma)

Storage Instructions

Room Temp., Refrigerated (2-8 C)

Stability Requirements

Room temp. 7 days, Refrigerated 7 days

Causes for Rejection

Samples unspun or improperly spun; gross hemolysis; improper labeling, QNS.

Test Details

Use

Lipase measurements are used in the diagnosis and treatment of diseases of the pancreas, such as acute pancreatitis and obstruction of the pancreatic duct.

Methodology

Spetctrophotometric

Reference Interval

12-53 U/L

Additional Information

Lipase is a pancreatic enzyme responsible for breaking down dietary fats into fatty acids and glycerol. It is secreted primarily by the pancreas and functions in the small intestine. In healthy individuals, serum lipase levels are low; however, damage or inflammation of the pancreas leads to increased leakage of lipase into the bloodstream, making it a key biomarker for acute pancreatitis.

Clinically, lipase is preferred over amylase for diagnosing pancreatitis due to its higher sensitivity and longer half-life in serum. Elevated lipase levels may also be seen in other conditions such as pancreatic cancer, renal failure, cholecystitis, and gastrointestinal perforation, though levels are typically not as high as in pancreatitis. In acute pancreatitis, levels typically rise within 4–8 hours of onset, peak at 24 hours, and remain elevated for up to 14 days.

Reference:
Yadav, D., & Lowenfels, A. B. (2013). The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology, 144(6), 1252–1261. https://doi.org/10.1053/j.gastro.2013.01.068

Footnotes

Statement on Medical Necessity
All ordered tests should be medically necessary for the diagnosis or detection of disease, illness, impairment, symptom, syndrome, or disorder and the results should be used in the medical management and treatment decisions for the patient. Solaris requires ICD-10 codes with each order for lab testing and both the tests ordered and the diagnosis should be documented in the provider’s medical record for the patient. The United States Department of Health and Human Services, Office of Inspector General, takes the position that a provider who orders medically unnecessary tests may be subject to civil penalties.

Panels and Profiles
Solaris offers Providers the convenience of ordering test combinations in a group at times with the flexibility to choose appropriate test(s) for individual patients. Providers should only order those tests that he or she believes are medically necessary for each patient, and a lesser inclusive profile or individual tests should be ordered if not all tests in the test combination/profile are medically necessary. All tests offered in a test combination/profile may be ordered separately as individual tests. Solaris encourages clients to contact their Solaris representative if the testing configurations shown do not meet individual needs for any reason, or if some other combination of procedures is needed.

CPT Codes
CPT Codes listed are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are the responsibility of the billing party and are listed here for informational purposes. Correct coding may vary from one carrier to another. Solaris may bill specific carriers using codes other than what is shown.

Questions?

For questions or inquiries related to testing please reach out to
customerservice@solarisdx.com or contact us by phone at (844) 550-0308.